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Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: Here, we reposition decitabine for triple-negative breast cancer (TNBC), a subtype with frequent p53

Keywords： p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

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Negative Energy in Faster Than Light Investigation ——An Important Direction to Researches

Huang Zhixun

Strategic Study of CAE 2001, Volume 3, Issue 7,   Pages 42-47

Abstract:

This paper describes a series of expectations and experiments on the negative energy notion.The aim is to find the relation between the faster-than-light research and the negative energy concepts

Keywords： negative energy     faster than light     Casimir's effect     evanescent mode     negative refraction index    

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Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 1-10 doi: 10.1007/s11684-020-0741-5

Abstract: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with a heterogeneous

Keywords： triple-negative breast cancer     immunotherapy     targeted therapy    

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Field validation of UHPC layer in negative moment region of steel-concrete composite continuous girder

Minghong QIU; Xudong SHAO; Weiye HU; Yanping ZHU; Husam H. HUSSEIN; Yaobei HE; Qiongwei LIU

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 6,   Pages 744-761 doi: 10.1007/s11709-022-0843-z

Abstract: Improving the cracking resistance of steel-normal concrete (NC) composite beams in the negative momentThis study proposed an innovative structural configuration for the negative bending moment region inIn order to investigate the feasibility and effectiveness of this new UHPC jointed structure in the negativefield investigation, strains on the surface of the concrete bridge deck, rebar, and steel beam in the negativedemonstrated that the new configuration with the UHPC layer provided an effective alternative for the negative

Keywords： field test     steel-concrete composite beam     continuous girder bridge     negative bending moment region    

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Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breastcancer was similar in node-negative diseases: a single-center study of 800 patients

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 621-628 doi: 10.1007/s11684-020-0738-0

Abstract: Chinese patients with pN0-1, estrogen receptor-positive (ER ), human epidermal growth factor receptor 2-negative

Keywords： early breast cancer     21-gene assay     recurrence score     prognosis    

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The Negative Electrostatic Spring Effect Analysis and Experimental Validation of Silicon Micromechanical

Xia Dunzhu,Zhou Bailing,Wang Shourong

Strategic Study of CAE 2007, Volume 9, Issue 8,   Pages 66-68

Abstract:  The negative electrostatic spring effect of feedback force generator is analyzed in focus,  

Keywords： silicon micromechanical z-axis gyroscope     negative electrostatic spring constant     feedback force generator    

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Recent Advances in Physical Optics Research

Huang Zhixun

Strategic Study of CAE 2006, Volume 8, Issue 2,   Pages 18-29

Abstract: experimental studies of the physical optics, such as the Goos-Hänchen shift, the FTIR phenomena, the negative

Keywords： physical optics     negative wave velocity     negative refraction index     GH shift     evanescent waves     photon rest    

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The negative ring demolition and tunnel refitting technique of large diameter tube

Zhai Zhiguo,Huang xuejun,Yang Zhiyong

Strategic Study of CAE 2010, Volume 12, Issue 12,   Pages 83-88

Abstract:

Through introducing the construction method of negative ring demolitionhead and replacement technique of Beijing Rail Transit Line 2 bid section in detail, the experience of negative

Keywords： big diameter shield     negative ring     demolition     tunnel reconstruction    

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homogeneous charge compression ignition combustion in a two-cylinder gasoline direct injection engine with negative

WANG Zhi, WANG Jianxin, SHUAI Shijin, MA Qingjun, TIAN Guohong

Frontiers in Energy 2007, Volume 1, Issue 3,   Pages 311-315 doi: 10.1007/s11708-007-0045-3

Abstract: this paper, HCCI combustion was studied in a two-cylinder gasoline direct injection (GDI) engine with negativeA two-stage gasoline direct injection strategy combined with negative valve overlap was used to control

Keywords： Homogeneous     control     combustion     consumption     extension    

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Mitigating Climate Change Will Depend on Negative Emissions Technologies

Chris Palmer

Engineering 2019, Volume 5, Issue 6,   Pages 982-984 doi: 10.1016/j.eng.2019.10.006

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Negative weights in network time model

Zoltán A. VATTAI, Levente MÁLYUSZ

Frontiers of Engineering Management 2022, Volume 9, Issue 2,   Pages 268-280 doi: 10.1007/s42524-020-0109-1

Abstract: A negative duration, such as “time period” at first sight is difficult to interpret.Previous network techniques (CPM/PERT/PDM) did not support negative parameters and/or loops (potentiallyMonsieur Roy and John Fondahl implicitly introduced negative weights into network techniques to representSubsequently, the introduction of negative lead and/or lag times by software developers (IBM) apparentlyovercome the limitation of not allowing negative time parameters in time model.

Keywords： graph technique     network technique     construction management     scheduling    

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resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor receptor 2-negative

Wenjie Zhu, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 208-220 doi: 10.1007/s11684-020-0795-4

Abstract: New targeted therapies have been developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR /HER2 advanced breast cancer (ABC). We conducted a meta-analysis and systemic review on randomized controlled trials evaluating various targeted therapies in combination with ET in HR /HER2 ABC. PUBMED and EMBASE databases were searched for eligible trials. Hazard ratios (HRs) for progression-free survival (PFS), odds ratios (ORs) for objective response rate (ORR), clinical benefit rate (CBR), and toxicity were meta-analyzed. Twenty-six studies with data on 10 347 patients were included and pooled. The addition of cyclin-dependent kinase 4/6 inhibitors to ET significantly improved median PFS (pooled HR= 0.547, <0.001), overall survival (pooled HR= 0.755, <0.001), and tumor response rates (ORR, pooled OR= 1.478, <0.001; CBR, pooled OR= 1.201, <0.001) with manageable toxicities (pooled OR= 3.280, <0.001). The mammalian targets of rapamycin inhibitors and exemestane were not clinically beneficial for this pooled population including ET-naïve and ET-resistant patients. Moderate improvement in PFS (pooled HR= 0.686, <0.001) yet pronounced toxicities (pooled OR= 2.154, <0.001) were noted in the combination of phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitors with fulvestrant. Future studies are warranted to optimize the population and the dosing sequence of these available options.

Keywords： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials     meta-analysis     targeted therapy    

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Negative Energy Problem-An Important Direction of Superluminal Speed Research""> A Brief Comment on "Negative Energy Problem-An Important Direction of Superluminal Speed Research"

耿天明

Strategic Study of CAE 2001, Volume 3, Issue 7,   Pages 94-94

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SEQUESTERING ORGANIC CARBON IN SOILS THROUGH LAND USE CHANGE AND AGRICULTURAL PRACTICES: A REVIEW

Frontiers of Agricultural Science and Engineering 2023, Volume 10, Issue 2,   Pages 210-225 doi: 10.15302/J-FASE-2022474

Abstract:

● Either increasing C input to or reducing C release from soils can enhance soil C sequestration.

Keywords： agroecosystems     climate change     negative emissions technology     net zero    

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Emerging Negative Warming Impacts on Tibetan Crop Yield

Dorji Tsechoe, Shilong Piao, Xuhui Wang, Chuang Zhao, Baohua Liu, Anping Chen, Shiping Wang, Tao Wang

Engineering 2022, Volume 14, Issue 7,   Pages 163-168 doi: 10.1016/j.eng.2021.01.012

Abstract: crop yield shifted from nonsignificant (P > 0.10) in the 1980s and 1990s to significantly negativeThe emerging negative impacts of higher temperatures suggest an increasing vulnerability of Tibetan croplands

Keywords： Tibet     Warming     Crop yield     Barley     Negative warming impacts    

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Title Author Date Type Operation

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Journal Article

Negative Energy in Faster Than Light Investigation ——An Important Direction to Researches

Huang Zhixun

Journal Article

Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

Journal Article

Field validation of UHPC layer in negative moment region of steel-concrete composite continuous girder

Minghong QIU; Xudong SHAO; Weiye HU; Yanping ZHU; Husam H. HUSSEIN; Yaobei HE; Qiongwei LIU

Journal Article

Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breastcancer was similar in node-negative diseases: a single-center study of 800 patients

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

Journal Article

The Negative Electrostatic Spring Effect Analysis and Experimental Validation of Silicon Micromechanical

Xia Dunzhu,Zhou Bailing,Wang Shourong

Journal Article

Recent Advances in Physical Optics Research

Huang Zhixun

Journal Article

The negative ring demolition and tunnel refitting technique of large diameter tube

Zhai Zhiguo,Huang xuejun,Yang Zhiyong

Journal Article

homogeneous charge compression ignition combustion in a two-cylinder gasoline direct injection engine with negative

WANG Zhi, WANG Jianxin, SHUAI Shijin, MA Qingjun, TIAN Guohong

Journal Article

Mitigating Climate Change Will Depend on Negative Emissions Technologies

Chris Palmer

Journal Article

Negative weights in network time model

Zoltán A. VATTAI, Levente MÁLYUSZ

Journal Article

resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor receptor 2-negative

Wenjie Zhu, Binghe Xu

Journal Article

A Brief Comment on "Negative Energy Problem-An Important Direction of Superluminal Speed Research"

耿天明

Journal Article

SEQUESTERING ORGANIC CARBON IN SOILS THROUGH LAND USE CHANGE AND AGRICULTURAL PRACTICES: A REVIEW

Journal Article

Emerging Negative Warming Impacts on Tibetan Crop Yield

Dorji Tsechoe, Shilong Piao, Xuhui Wang, Chuang Zhao, Baohua Liu, Anping Chen, Shiping Wang, Tao Wang

Journal Article